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本文采用由中国医学科学院卫生研究所供应的、南栗煤矿煤矸石和纯盐酸制成的聚合氯化铝对小白鼠进行急性动物试验。聚合氯化铝按4000、4600、5300、6100和7000毫克/公斤的剂量分为五组,每个剂量组的受试小白鼠雌、雄各十只,用聚合氯化铝的水混悬液空腹灌胃给药。给药后,小白鼠行动蹒躇、神态萎糜、鼠毛蓬松。给药六小时后,低剂量组小鼠陆续恢复饮食,上述情况消失。高剂量组小鼠在给药三、四小时后,先后出现死亡。死鼠胃极度膨胀,胃内充满黄褐色透明液体,胃壁变薄呈半透明膜状。根据给药后一周内各组小鼠死亡情况,用平均剂量法算出LD_(50)和95％可信限、雌、雄鼠分别为4854毫克/公斤(4512—5222毫克/公斤)和5201毫克/公斤(4808—5626毫克/公斤),两者的显著性测验t=1.3<1.96,P<0.05,差别无显著意义。据此,聚合氯化铝(南栗产品)应属实际无毒级。急性毒性很低,
In this article, acute animal experiments on mice were performed using polyaluminum chloride made from coal gangue and pure hydrochloric acid supplied by the Institute of Health Sciences, Chinese Academy of Medical Sciences. Polyaluminum chloride was divided into five groups according to doses of 4000, 4600, 5300, 6100 and 7000 mg/kg. Each dose group consisted of ten test female mice and ten males. Aqueous suspension of polyaluminum chloride was used. Fasting oral administration. After dosing, the mice acted swiftly, they looked sluggish, and the rats had fluffy hair. Six hours after the administration, mice in the low-dose group gradually resumed their diets, and the above situation disappeared. The mice in the high-dose group died three or four hours after administration. The dead rat’s stomach was extremely swollen, and the stomach was filled with a yellow-brown transparent liquid, and the stomach wall became thinner and translucent. According to the deaths of mice in each group within one week after administration, the average dose method was used to calculate the LD_(50) and 95% confidence limits. The female and male rats were 4,854 mg/kg (4512–5222 mg/kg) and 5,201 mg, respectively. /kg (4808-5626 mg/kg), both significant test t = 1.3 <1.96, P <0.05, the difference was not significant. Accordingly, polyaluminum chloride (Nanli product) should be practically nontoxic. Acute toxicity is low,