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目的:研究妇产血净防治药物流产后出血的作用机理。方法:将50只药流模型大鼠随机分为模型组、益母草对照组、妇产血净高、中、低剂量组各10只,用免疫组化及酶联免疫吸附法检测大鼠血清中胎盘催乳素(PL)、胎盘特异性糖蛋白(PSβ1G)、胎盘碱性磷酸酶(PALP)和细胞凋亡第八因子相关抗原(F-ⅧRAg)。结果:妇产血净可明显降低药流后大鼠血清中PL、PSβ1G、PALP、F-ⅧRAg的含量(P<0.05,P<0.01)。结论:妇产血净减少药物流产后出血的机制可能与抑制PL、PSβ1G、PALP、F-ⅧRAg的分泌,从而促进残留蜕膜排出有关。
OBJECTIVE: To study the mechanism of maternal blood net prevention and treatment of drug-induced abortion hemorrhage. METHODS: Fifty rats of drug-flow model were randomly divided into model group, motherwort control group, and each group of 10 high-dose, mid-low-dose and high-dose groups. The placenta of rat serum was detected by immunohistochemistry and enzyme-linked immunosorbent assay. Prolactin (PL), placenta-specific glycoprotein (PSβ1G), placental alkaline phosphatase (PALP) and apoptosis-associated factor VIII related antigen (F-VIIIRAg). RESULTS: FBS could significantly reduce the levels of PL, PSβ1G, PALP and F-VIIIRAg in serum of rats after drug flow (P<0.05, P<0.01). Conclusions: The mechanism of postpartum hemorrhage of obstetrics and blood loss may be related to the inhibition of the secretion of PL, PSβ1G, PALP, and F-VIIIRAg, thereby promoting the release of residual decidua.