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目的:探讨射频治疗在局部晚期非小细胞肺癌综合治疗中的作用。方法:随机将不能切除的Ⅲ期非小细胞肺癌的患者分别纳入综合组和常规组,常规组给予放疗和化疗;综合组在放化疗的基础上加原发灶射频治疗。结果:60例患者进入研究。综合组KPS改善率明显优于常规组(62.07%,21.42%;P=0.02);原发灶局部复发率综合组显著低于常规组(17.2%,42.9%;P=0.017);中位生存期综合组15个月,常规组14个月;1、2年生存率综合组稍高于常规组(78.65%,60.29%;39.84%,27.83%),但两组间比较无统计学意义。结论:射频治疗可有效地降低不可切除的Ⅲ期非小细胞肺癌的局部复发率,改善患者功能状态;但无明显提高不可切除的Ⅲ期非小细胞肺癌1、2年生存率。
Objective: To investigate the role of radiofrequency ablation in the treatment of locally advanced non-small cell lung cancer. Methods: Patients with unresectable stage Ⅲ non-small cell lung cancer were randomly divided into the combined group and the conventional group. The conventional group was given radiotherapy and chemotherapy. The combined group was treated with radiofrequency and radiofrequency ablation based on the radiotherapy and chemotherapy. Results: Sixty patients entered the study. The improvement rate of KPS in the comprehensive group was significantly higher than that in the conventional group (62.07%, 21.42%; P = 0.02). The local recurrence rate in the primary group was significantly lower than that in the conventional group (17.2%, 42.9%; P = 0.017) The patients in the combination group were 15 months old and 14 months in the conventional group. The 1-year and 2-year survival rates in the comprehensive group were slightly higher than those in the conventional group (78.65%, 60.29%, 39.84%, 27.83%), but there was no significant difference between the two groups. Conclusion: Radio-frequency therapy can effectively reduce the local recurrence rate of unresectable stage Ⅲ non-small cell lung cancer and improve the functional status of patients. However, it does not significantly improve the one-and-two-year survival rate of unresectable stage Ⅲ non-small cell lung cancer.