论文部分内容阅读
目的:研究女性高血压并发不稳定型心绞痛患者血清脂蛋白(a)[Lp(a)]水平的变化。方法:对124例拟诊为不稳定型心绞痛的女性高血压患者分别测定血总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和Lp(a)水平,并行选择性冠状动脉造影明确诊断。结果:冠状动脉造影确诊为冠心病者77例(冠心病组),血清TC、TG、LDL-C、HDL-C和Lp(a)水平分别为(6·11±1·15)、(1·89±1·06)、(3·92±1·31)、(1·04±0·25)mmol/L和(279·84±309·31)mg/L。冠状动脉造影除外冠心病者(对照组)47例,血清TC、TG、LDL-C、HDL-C和Lp(a)水平分别为(5·59±1·02)、(1·85±0·78)、(3·08±0·71)、(1·20±0·59)mmol/L和(187·13±145·42)mg/L。冠心病组血清TC、TG、LDL-C和HDL-C水平与对照组比较差异无统计学意义,而Lp(a)较对照组显著升高(P<0·05)。Lp(a)水平与TC和LDL-C呈正相关。结论:女性高血压并发不稳定型心绞痛患者血清Lp(a)水平升高。
Objective: To investigate the changes of serum lipoprotein (a) [Lp (a)] level in women with hypertension complicated by unstable angina pectoris. Methods: A total of 124 hypertensive women with unstable angina pectoris were enrolled in this study. Blood TC, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol HDL-C) and Lp (a) levels, with concurrent diagnosis of selective coronary angiography. Results: Serum TC, TG, LDL-C, HDL-C and Lp (a) were detected in coronary artery disease group by coronary angiography in 77 patients (CHD group) · 89 ± 1 · 06), (3 · 92 ± 1 · 31), (1 · 04 ± 0 · 25) mmol / L and (279 · 84 ± 309 · 31) mg / L respectively. The levels of serum TC, TG, LDL-C, HDL-C and Lp (a) were (59 · ± 1 · 02) and (· · · · 85 ± 0) in 47 patients with coronary heart disease except coronary artery disease (control group) · 78), (3.08 ± 0.71), (1.20 ± 0.59) mmol / L and (187 · 13 ± 145 · 42) mg / L, respectively. The levels of TC, TG, LDL-C and HDL-C in CHD group were not significantly different from those in control group, but Lp (a) was significantly higher than that in control group (P <0.05). The level of Lp (a) was positively correlated with TC and LDL-C. Conclusion: The level of serum Lp (a) is elevated in patients with hypertension complicated by unstable angina pectoris.