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目的观察在血药浓度监测下由多药改为单药治疗癫痫的疗效。方法监测 30例血药浓度 ,所有患者均出现 1种以上血药浓度不足或过量 ,经减药或单用苯妥英钠、丙戊酸钠 ,卡马西平。结果 8例发作消失 ,7例发作减少 75 %以上 ,4例减少发作 5 0 %以上 ;6例发作频率无变化 ,但发作程度减轻 ;5例发作频率增加 ,拒绝减药治疗。结论单药应用效果满意 ,但应进行血药浓度监测
Objective To observe the curative effect of multi-drug to monotherapy in the monitoring of serum concentration of epilepsy. Methods Thirty cases of plasma concentration were monitored. All patients showed more than one plasma concentration was inadequate or overdose. The patients were treated with either phenytoin, sodium valproate or carbamazepine. Results The seizures disappeared in 8 patients. The seizures in 7 patients were reduced by 75% or more, and those in 4 patients were reduced by more than 50%. The seizure frequency was unchanged in 6 patients, but the seizure frequency was reduced. Conclusion The single drug is satisfactory, but blood concentration should be monitored