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A series of arylpiperazinesquinazoline-2,4-diamine compounds were designed and synthesized based on pharmacophore for uro-selectiveα_1-adrenoceptor antagonists and 3D chemical database searching.The in vitro functional analysis showed that compounds 9 and 14 showed better and similarα_1-AR antagonistic activity compared with prazosin.
A series of arylpiperazinesquinazoline-2,4-diamine compounds were designed and synthesized based on pharmacophore for uro-selective α 1-adrenoceptor antagonists and 3D chemical database searching. In vitro functional analysis showed that compounds 9 and 14 showed better and similar α 1-AR antagonistic activity compared with prazosin.