论文部分内容阅读
目的:探讨血清β2微球蛋白(β2-MG)和胱抑素C(Cys C)检测在高胆红素血症新生儿肾功能损害中的应用及其临床意义。方法:选择本院足月产高胆红素血症新生儿304例作为观察组,按血清总胆红素水平和日龄大小分组,选同期非高胆红素血症新生儿50例作为对照组。检测所有新生儿血清β2-MG、Cys C、Cr、BUN水平,对检测结果进行统计学分析。结果:高胆红素血症新生儿(观察组)的血清Cr、BUN水平与对照组之间差异不大(P均﹥0.05);而血清β2-MG和Cys C水平显著高于对照组(P<0.05),但不同分组的组间差异不大(P均﹥0.05)。观察组血清β2-MG和Cys C水平与Cr、BUN水平之间均有一定的相关性(P均<0.05),而β2-MG与Cys C之间高度相关(r=0.760,P<0.05)。结论:血清β2-MG和Cys C是较Cr、BUN更为敏感、准确的诊断新生儿高胆红素血症早期肾功能损害的指标。
Objective: To investigate the clinical application of serum β2-microglobulin (β2-MG) and cystatin C (Cys C) in renal damage in neonates with hyperbilirubinemia. Methods: A total of 304 newborns with full-bodied hyperbilirubinemia in our hospital were selected as the observation group. The levels of serum total bilirubin and age were divided into groups. Fifty newborns with non-hyperbilirubinemia during the same period were selected as control group group. The levels of β2-MG, Cys C, Cr and BUN in all neonates were detected and the results were statistically analyzed. Results: Serum levels of Cr and BUN in neonates with hyperbilirubinemia (observation group) were not significantly different from those in the control group (all P> 0.05), while serum levels of β2-MG and Cys C were significantly higher than those in the control group P <0.05), but there was no significant difference between groups (P> 0.05). The serum levels of β2-MG and Cys C in the observation group were significantly correlated with Cr and BUN levels (all P <0.05), while β2-MG and Cys C were highly correlated (r = 0.760, P <0.05) . Conclusions Serum β2-MG and Cys C are more sensitive and accurate indicators of early renal dysfunction in neonates with hyperbilirubinemia than Cr and BUN.