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随着年龄的增长,造血干细胞逐渐失去了维持造血系统再生的能力,并且抵抗疾病的能力也随之降低。自噬与健康长寿息息相关,而且是保护造血干细胞抵御代谢应激损伤的关键。Ho等的研究发现,如果造血干细胞失去自噬的能力,会造成线粒体的累积和代谢状态的激活,进而通过表观遗传失调机制加速骨髓分化并且损害造血干细胞的自我更新能力和再生潜力。最关键的是,老年小鼠的大部分造血干细胞都会出现上述代谢和功能特征的改变。然而,大约三分之一的衰老造血干细胞表
With age, hematopoietic stem cells gradually lose their ability to maintain the regeneration of the hematopoietic system, and the ability to resist disease is also reduced. Autophagy is closely related to health and longevity, and it is the key to protect hematopoietic stem cells against metabolic stress injury. Ho et al. Found that if hematopoietic stem cells lose autophagy, they can cause accumulation of mitochondria and activation of metabolic states, thereby accelerating myeloid differentiation and impairing the self-renewal and regeneration potential of hematopoietic stem cells through epigenetic disorders. Most critically, most of the hematopoietic stem cells in older mice undergo these metabolic and functional changes. However, about one-third of the tables of aging hematopoietic stem cells