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本文应用分子生物学技术流式细胞分析法进行卵巢癌与术后复发者实体瘤组织、外周血粘附分子ＣＤ４４的含量测定。结果表明：正常人与良性肿瘤外周血ＣＤ４４含量分别为４．８３％、７．６２％，明显低于卵巢癌２７．０１％与复发转移者３８．１％（Ｐ＜０．０１）有显著差异，且ＣＤ４４含量于恶性肿瘤的外周血、腹水、实体组织中均呈高水平表达、其间无明显差异。提示ＣＤ４４粘附分子与癌转移密切相关。进而文章对ＣＤ４４在癌转移的作用进行讨论。临床验证认为外周血ＣＤ４４含量检测可做为患者术后监测疗效观察及癌转移早期诊断指标
In this paper, molecular biology techniques flow cytometric analysis of ovarian cancer and recurrence of solid tumor tissue, peripheral blood adhesion molecule CD44 content determination. The results showed that the levels of CD44 in peripheral blood of normal and benign tumors were 4.83% and 7.62% respectively, which was significantly lower than that of ovarian cancer 27.01% and 38.1% of those with recurrence (P<0.01). Differences, and CD44 content in malignant tumors in peripheral blood, ascites, solid tissue showed high levels of expression, there was no significant difference. It is suggested that CD44 adhesion molecules are closely related to cancer metastasis. Further, the article discusses the role of CD44 in cancer metastasis. The clinical test shows that the detection of CD44 in peripheral blood can be used as an early diagnostic indicator for monitoring and early diagnosis of cancer metastasis.