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Cefuroxime axetil(CXM-AM、格兰素)是通过用1-乙酰氧乙基将头孢呋新4位上的羧基酯化来提高脂溶性,增大在消化道吸收的第二代口服头孢菌素类药物,结构式如下图。
Cefuroxime axetil (CXM-AM, Glaxo) is a lipid-solubilizing agent that increases the liposolubility by esterifying the carboxyl group at position 4 of cefuroxime with 1-acetoxyethyl and increases the absorption of the second-generation oral cephalosporins Class drugs, structural formula as shown below.