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目的建立面肌痉挛的动物模型，以探讨其发病机理。方法28只新西兰大白兔随机分为4组：面神经脱髓鞘并血管压迫组（模型组）13只；单一面神经血管压迫组5只；单一面神经脱髓鞘组5只；假手术对照组5只。术后第3、6周，分别用电生理技术检测面肌痉挛所特有的异常肌反应（AMR）。结果术后第3周，4组动物均未诱发出AMR：模型组有10只动物于术后第6周诱发出明显的AMR，而其他各组动物仍未诱发出AMR。结论面神经脱髓鞘和血管压迫是引起面肌痉挛的两个必要条件；建立合适的面肌痉挛动物模型为进一步研究其发病机理提供厂良好的实验基础。
Objective To establish an animal model of hemifacial spasm to explore its pathogenesis. Methods Twenty-eight New Zealand white rabbits were randomly divided into 4 groups: facial demyelination and vascular compression group (model group) 13; facial nerve vascular compression group 5; single facial nerve demyelination group 5; sham operation control group 5 . At 3 and 6 weeks after operation, electrophysiological techniques were used to detect abnormal muscle responses (AMRs) that were specific to hemifacial spasm. Results AMR was not induced in all three groups at the third week after operation. Ten animals in the model group developed significant AMR at the sixth week after operation, while AMR was not observed in the other groups. Conclusion Facial nerve demyelination and vascular compression are the two necessary conditions that cause hemifacial spasm. Establishing a suitable animal model of hemifacial spasm provides a good experimental basis for further study of its pathogenesis.