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目的探讨三维适形放疗(3DCRT)和EP方案同步化疗治疗Ⅲ期非小细胞肺癌(NSCLC)的疗效和毒副反应。方法100例患者随机分为治疗组和对照组,每组50例。治疗组采用3DCRT+EP方案,放疗每次3 Gy,总剂量DT66 Gy,22次,4.5周;对照组用常规放疗+EP方案,放疗DT66 Gy,33次,6.5周。两组均于放疗第1、29天各用EP方案化疗一次。结果治疗组有效率84%,明显高于对照组的66%(P<0.05)。治疗组1、3、5年生存率分别为78%、36%、18%,亦明显高于对照组的62%、28%、8%(P<0.05)。治疗组放射性肺炎发生率较对照组低(P<0.05)。结论3DCRT加EP方案同步治疗Ⅲ期非小细胞肺癌,近期疗效较好,提高了生存率,照射野的缩小,使放疗毒副反应减轻,改善了生存质量。
Objective To investigate the efficacy and toxicities of three-dimensional conformal radiotherapy (3DCRT) and EP regimen in the treatment of stage Ⅲ non-small cell lung cancer (NSCLC). Methods 100 patients were randomly divided into treatment group and control group, 50 cases in each group. The patients in the treatment group received 3DCRT + EP regimen. The total radiation dose was 3 Gy and the total dose was DT66 Gy, 22 and 4.5 weeks respectively. The control group received conventional radiotherapy and EP regimen and received DT66 Gy, 33 and 6.5 weeks of radiotherapy. The two groups were treated with EP regimen on the first and twelfth day after radiotherapy. Results The effective rate of the treatment group was 84%, which was significantly higher than that of the control group (66%, P <0.05). The 1, 3, 5-year survival rates of the treatment group were 78%, 36% and 18% respectively, which were also significantly higher than those of the control group (62%, 28% and 8%, P <0.05). The incidence of radiation pneumonitis in the treatment group was lower than that in the control group (P <0.05). Conclusions 3DCRT plus EP regimen in the treatment of stage Ⅲ non-small cell lung cancer simultaneously has a good curative effect in the short term, which improves the survival rate and reduces the irradiation field, alleviating the radiotherapy side effects and improving the quality of life.