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目的研究移植性肾小球病（ＴＧＰ）的病理形态与慢性肾移植排斥反应的关系及其临床意义。方法对６２例ＴＧＰ的穿刺活检组织进行光镜、免疫荧光和电镜研究。结果（１）慢性肾移植排斥反应是肾移植失败的主要原因（占２０．５％），常导致蛋白尿、高血压和肾功能下降。（２）ＴＧＰ是慢性肾移植排斥反应的主要病变（占２４％）。特征是肾小球膜性增生，表现为基膜增厚、内疏松层增宽，内含多形性、异源性包涵物，内皮细胞或系膜细胞增生插入基膜。结论慢性肾移植排斥反应中，肾小球毛细血管是损伤的靶组织，可能参与ＴＧＰ的发病
Objective To study the relationship between the pathological features of transplant glomerular disease (TGP) and the rejection of chronic renal allograft and its clinical significance. Methods Sixty-two TGP biopsy specimens were examined by light microscopy, immunofluorescence and electron microscopy. Results (1) Chronic renal allograft rejection is the main cause of renal transplantation failure (20.5%), often resulting in proteinuria, hypertension and renal function decline. (2) TGP is the main pathological change in chronic renal allograft rejection (24%). Characterized by glomerular membranous hyperplasia, manifested as thickening of the basement membrane, widened within the loose layer, containing pleomorphic, heterogeneous inclusions, endothelial cells or mesangial cell proliferation inserted into the basement membrane. Conclusion In the rejection of chronic renal allograft, glomerular capillaries are the target of injury and may be involved in the pathogenesis of TGP