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AIM:To investigate the clinical and virological course ofcoinfection by hepatitis B virus (HBV) and hepatitis C virus(HCV) in China.METHODS:We enrolled 40 patients with chronic HBV andHCV coinfection (Group BC),16 patients with chronic HBVinfection (Group B) and 31 patients with chronic HCV infection(Group C).They infected HBV and/or HCV during 1982 to 1989.Sera of all the 87 patients were collected in 1994 and 2002respectively.We detected biochemical and virologic markersand serum HBV DNA and HCV RNA levels of all the patients.B-type ultrasound detection was performed in some patients.RESULTS:In Group BC,67.5 % of the patients cleared HBsAg,and 92.5 % of the patients cleared HBeAg.The clearance rateof HBV DNA was 87.5 %.There was no significant differenceof HBV clearance between Group BC and Group B.In GroupBC,85.7 % of males and 47.4 % of females cleared HBV,andmales were easier to clear HBV (χ~2=6.686,P=0.010).Such atendency was also found in Group B.The clearance rate ofHCV RNA in Group BC was 87.5 %,significantly higher thanthat in Group C (χ~2=22.963,P<0.001).Less than 40 % of thepatients in all groups had elevated liver enzyme values.Thehighest value of alanine aminotransferase (ALT) was 218 u/L(normal range for ALT is 0-40 u/L).In most patients theultrasonogram presentations changed mildly.CONCLUSION:The clinical manifestations of patients withHBV/HCV coinfection are mild and occult.High clearancerate of HBV and easy to clear HBV in male patients are thecharacteristics of HBV infection in adults in China.HBV caninhibit HCV replication,but no evidence has been found inour data that HCV suppresses HBV replication.
AIM: To investigate the clinical and virological course of coinfection by hepatitis B virus (HBV) and hepatitis C virus (HCV) in China. METHODS: We enrolled 40 patients with chronic HBV and HCV coinfection (Group BC), 16 patients with chronic HBV infection B) and 31 patients with chronic HCV infection (Group C). They infected HBV and / or HCV during 1982 to 1989. Sera of all the 87 patients were collected in 1994 and 2002 were researchers. We detected biochemical and virologic markers and serum HBV DNA and HCV RNA levels of all the patients. B-type ultrasound detection was performed in some patients .RESULTS: In Group BC, 67.5% of the patients cleared HBsAg, and 92.5% of the patients cleared HBeAg. The clearance rate of HBV DNA was 87.5%. There was no significant difference between HBV clearance between the Group BC and Group B. In GroupBC, 85.7% of males and 47.4% of females cleared HBV, and males were easier to clear HBV (χ ~ 2 = 6.686, P = 0.010) .Such atendency was also found in Group B. The clearance rate of HCV RNA in Group BC was 87.5%, significantly higher thanthat in Group C (χ ~ 2 = 22.963, P <0.001). Less than 40% of the patients in all groups had elevated liver enzyme values. The histogram of alanine aminotransferase (ALT) was 218 u / L (normal range for ALT is 0-40 u / L) .In most patients theultrasonogram presentations changed mildly. CONCLUSION: The clinical manifestations of patients with HBV / HCV coinfection are mild and occult. High clearance rate of HBV and easy to clear HBV in male patients are the characteristics of HBV infection in adults in China. HBV caninhibit HCV replication, but no evidence has been found in data that HCV suppresses HBV replication.