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1978年8月～1995年2月间美国印第安那医科大学发现10例妇科恶性肿瘤乳腺转移病例,其中9例白种人,1例黑人。2例的亲属患有乳腺癌,但无BRCA1基因突变的家族遗传病史。妇癌确诊时的平均年龄为56.8(30～80)岁。本组中卵巢癌5例,宫颈癌2例,阴道癌、子宫内膜癌及浆膜癌各1例。在卵巢癌患者中,3例为浆液性乳头状癌,2例为透明细胞腺癌。卵巢恶性肿瘤患者平均年龄为51. 8(30～80)岁。转移后预后极差,平均存活期7个月。
Between August 1978 and February 1995, 10 cases of breast metastases from gynecologic malignancies were discovered by Indiana University of Medical Sciences. Among them, 9 cases were Caucasian and 1 was black. Two of the relatives had breast cancer, but no family history of BRCA1 mutations. The average age of women diagnosed with gynecological cancer was 56.8 (30-80) years old. There were 5 cases of ovarian cancer, 2 cases of cervical cancer, 1 case of vaginal cancer, endometrial cancer and serous membrane cancer in this group. Among ovarian cancer patients, 3 were serous papillary carcinomas and 2 were clear cell adenocarcinomas. The average age of ovarian cancer patients was 51.8 (30-80) years old. The prognosis after metastasis is very poor, with an average survival of 7 months.