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目的:探讨血清N末端B型钠尿肽原(NT-proBNP)与心脏型脂肪酸结合蛋白(H-FABP)与高血压性脑出血患者近期预后的相关性分析。方法:选取我院收治的160例高血压脑出血患者为研究对象,检测患者入院第1 d、3 d、7 d的血清NT-proBNP、H-FABP水平,按照入院后3个月的改良Rankin量表(m RS)评分对患者的预后进行评估,分为预后良好组(m RS评分≤2分)及预后不良组(m RS评分>2分);比较两组相关指标的差异。用Logistic回归方程分析血清NT-proBNP、H-FABP与m RS评分的关系。结果:与预后良好组比较,预后不良组患者入院后3个月的m RS评分较高,而入院格拉斯哥昏迷量表评分(GCS)评分较低(P<0.05);预后不良组患者入院第3 d、7 d的血清NT-proBNP、H-FABP高于预后良好组(P<0.05);Spearman相关性分析提示入院第1 d、3 d、7 d的血清NT-proBNP、H-FABP分别与m RS评分呈正相关,而与GCS呈负相关(P<0.05);多因素Logistic回归分析显示:入院第3d、7d的血清NT-proBNP、H-FABP是高血压脑出血患者预后不良的独立危险因素(P<0.05)。结论:血清NT-proBNP、H-FABP与高血压脑出血患者的近期预后具有一定的相关性,可能是患者近期预后不良的独立危险因素。
Objective: To investigate the correlation between the serum N-terminal pro-T-peptide (N-terminal proBNP) and cardiac fatty acid binding protein (H-FABP) and the prognosis of patients with hypertensive intracerebral hemorrhage. Methods: A total of 160 patients with hypertensive intracerebral hemorrhage admitted to our hospital were enrolled in this study. Serum levels of NT-proBNP and H-FABP were detected on the 1st, 3rd, and 7th days after admission. According to the modified Rankin The prognosis of the patients was assessed by m RS score and divided into two groups according to the prognosis: good prognosis group (m RS score ≤2) and poor prognosis group (m RS score> 2). Logistic regression equation was used to analyze the relationship between serum NT-proBNP, H-FABP and mRS score. Results: Compared with the good prognosis group, the patients with poor prognosis had a higher mRS score at 3 months and a lower admission GCS score (P <0.05). Patients with poor prognosis were admitted to hospital at the 3rd Serum levels of NT-proBNP and H-FABP on day 7 and day 7 were significantly higher than those in the good prognosis group (P <0.05). Spearman correlation analysis showed that the serum levels of NT-proBNP and H-FABP on the 1st, 3rd, m RS scores were negatively correlated with GCS (P <0.05). Multivariate Logistic regression analysis showed that NT-proBNP and H-FABP at 3d, 7d after admission were independent risk factors for poor prognosis in patients with hypertensive intracerebral hemorrhage Factor (P <0.05). Conclusion: The serum NT-proBNP and H-FABP have some correlations with the recent prognosis of patients with hypertensive intracerebral hemorrhage and may be an independent risk factor for the recent poor prognosis.