论文部分内容阅读
目的探讨T2DM患者中SUA与相关基因的关联及交互作用。方法纳入1574例T2DM患者,采用基质辅助激光解吸电离飞行时间质谱技术对56个基因的86个SNP位点进行基因分型,运用PLINK软件进行关联分析及基因型交互作用分析。结果在T2DM患者中ABCG2(rs2231142)、PKHD1(rs9395706)、PDGFB(rs2285094)、LPHN3(rs6856526)及MC4R(rs17782313)基因的多态性与SUA水平相关(P<0.05)。同时,有6组基因存在交互作用(P<0.001)。结论 ABCG2、PKHD1、PDGFB、LPHN3及MC4R基因的多态性与T2DM患者SUA水平相关。
Objective To investigate the association and interaction between SUA and related genes in T2DM patients. METHODS: A total of 1574 patients with T2DM were enrolled. Genotyping was performed on 86 SNPs of 56 genes using matrix-assisted laser desorption / ionization time-of-flight mass spectrometry. PLINK software was used for association analysis and genotype interaction analysis. Results The polymorphisms of ABCG2 (rs2231142), PKHD1 (rs9395706), PDGFB (rs2285094), LPHN3 (rs6856526) and MC4R (rs17782313) were correlated with SUA level in T2DM patients (P <0.05). At the same time, there were six groups of genes interacting (P <0.001). Conclusion The polymorphisms of ABCG2, PKHD1, PDGFB, LPHN3 and MC4R are correlated with the level of SUA in T2DM patients.