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已知,气道中毒蕈碱型乙酰胆碱(M)受体所介导的效应是平滑肌收缩。研究它在哮喘时的变化及其与其他受体(例如β受体)的关系,对于阐述哮喘的发病机理,为临床治疗提供依据,都具有重要意义。我们曾经报告,实验性过敏性哮喘动物肺组织中M受体的最大结合容量(Bmax)明显增加。本研究是在对正常豚鼠肺组织中M受体进行检定的基础上,进一步观察了它们在哮喘时的变化及其时间过程,并结合神经递质测定和离体气管实验结果,对M受体变化的原因和意义作初步探讨。
It is known that the effect mediated by muscarinic acetylcholine (M) receptors in the airways is smooth muscle contraction. Studying its changes in asthma and its relationship with other receptors (eg, beta receptors) is of great importance for elucidating the pathogenesis of asthma and providing the basis for clinical treatment. We have previously reported that the maximal binding capacity (M max) of M receptors in experimental allergic asthmatic animals is significantly increased (Bmax). This study is based on the normal guinea pig lung tissue M receptor on the basis of further observation of their changes in the asthma and time course, combined with neurotransmitter determination and tracheal ex vivo results, the M receptor The reason and significance of the change make a preliminary discussion.