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Nek激酶家族(NIMA related k inases)作为中心体的调节因素并由于其同肿瘤发生的特殊关系逐渐被人们所重视。Nek家族目前发现了11个成员,该激酶家族同中心体及细胞周期密切相关,Nek家族在有丝分裂中参加G2-M期的关键点的调控,促进中心体成熟并影响染色体的浓集和纺锤体形成。正常或异常Nek激酶的异常表达可以导致中心体的质或量的异常,进而造成肿瘤的发生。
The Nek kinase family (NIMA related k inases) as a regulatory factor of the centrosome and because of its special relationship with the tumor has gradually been taken seriously. The Nek family currently has 11 members. The kinase family is closely related to the centrosome and cell cycle. The Nek family participates in the regulation of key points in the G2-M phase during mitosis, promoting centromere maturation and affecting chromosome concentration and spindles. form. Aberrant expression of normal or abnormal Nek kinase can lead to abnormal mass or quantity of the centrosome, which in turn may cause tumorigenesis.