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目的:探讨姜黄素防治脂肪肝家鸭模型的量效关系及安全性。方法:复制家鸭脂肪肝模型。整个实验分为两部分完成。第一次实验用成人等效剂量2倍、4倍、8倍的姜黄素进行干预,第二次实验用16倍、32倍的姜黄素干预。考查不同剂量姜黄素对脂肪肝家鸭肝指数、肝脏甘油三酯(TG)、血清甘油三酯(TG)、血清游离脂肪酸(FFA)、肝脂酶(HL)水平的影响,以及实验二中姜黄素对肝、肾功能的影响。并进行统计分析。结果:不同剂量姜黄素组与模型组比较均能明显降低肝指数、肝TG、血TG、血清FFA,提高HL活性。并对剂量具有依赖性,在剂量为20~80mg时随剂量递增,效果渐佳;但在剂量为160~320mg时随剂量增加效果降低。并且姜黄素组较模型组能明显改善肝肾功能指标。结论:姜黄素有较强的抗脂肪肝作用,其抗脂肪肝作用与剂量相关,最佳剂量范围为80~160mg。口服给药安全。
Objective: To investigate the dose-effect relationship and safety of curcumin in preventing and treating fatty liver ducks. Method: Duplicate duck fatty liver model. The entire experiment was completed in two parts. The first experiment was conducted with curcumin 2 times, 4 times, and 8 times the equivalent dosage of adults, and the second experiment was treated with curcumin 16 times and 32 times. To investigate the effects of different doses of curcumin on fatty liver liver duck index, liver triglyceride (TG), serum triglyceride (TG), serum free fatty acid (FFA), hepatic lipase (HL) levels, and experiment 2 The effect of curcumin on liver and kidney function. And perform statistical analysis. RESULTS: Compared with the model group, different doses of curcumin group significantly reduced liver index, hepatic TG, blood TG, serum FFA, and increased HL activity. Dependent on the dose, the dose increased from 20 to 80 mg with increasing dose, the effect was good; but at a dose of 160 ~ 320 mg, the effect of dose increase decreased. And curcumin group compared with the model group can significantly improve liver and kidney function indicators. Conclusion: Curcumin has a strong anti-fatty liver effect, and its anti-fatty liver effect is related to the dose. The optimal dose range is 80~160mg. Oral administration is safe.