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目的:分析评价四联疗法治疗胃溃疡幽门螺杆菌的疗效。方法:选取我院2011年1月-2014年1月间确诊为幽门螺杆菌感染的胃溃疡患者260例,随机分为观察组和对照组,每组患者各130例。观察组患者给予四联疗法治疗。对照组患者给予常规三联疗法治疗。观察比较两组患者的疗效和不良反应。结果:4周之后观察疗效,观察组患者的总有效率为94.61%(123/130),对照组的总有效率为81.54%(106/130),两组比较,P<0.05具有显著性差异,有统计学意义;观察组的幽门螺旋杆菌清除率明显优于对照组;两组的不良反应,P>0.05,无明显差别。结论:四联疗法治疗胃溃疡幽门螺杆菌疗效显著,值得临床推广。
Objective: To analyze and evaluate the curative effect of quadruple therapy on gastric ulcer caused by Helicobacter pylori. Methods: 260 patients with gastric ulcer diagnosed as Helicobacter pylori infection in our hospital from January 2011 to January 2014 were randomly divided into observation group and control group, with 130 cases in each group. Patients in the observation group were treated with quadruple therapy. Patients in the control group were given conventional triple therapy. The efficacy and adverse reactions of the two groups were observed and compared. Results: The curative effect was observed after 4 weeks. The total effective rate was 94.61% (123/130) in the observation group and 81.54% (106/130) in the control group. The difference between the two groups was significant (P <0.05) , With statistical significance; observation group H. pylori clearance rate was significantly better than the control group; two groups of adverse reactions, P> 0.05, no significant difference. Conclusion: The quadruple therapy is effective in treating gastric ulcer due to Helicobacter pylori, which deserves clinical promotion.