多脏器累及的亲表皮CD8~+ T细胞淋巴瘤1例

• 作 者: 沈小雁 施若非 金晓龙 费晓春 曹华 郑捷
• 机 构: 上海交通大学医学院附属瑞金医院皮肤科瑞金-耶鲁皮肤淋巴瘤治疗中心,上海交通大学医学院附属瑞金医院病理科,
• 出 处: 中国皮肤性病学杂志
• 发表日期: 2011年12期
• 关键词: 淋巴瘤 CD8 亲表皮 表皮 渗出性红斑 皮肤组织病理 基因重排 异型细胞 CHOP 侵袭性

患者男,46岁,全身渗出性红斑、头皮脓肿9月。入院检查发现累及肺、肝脏,皮肤组织病理示:表皮海绵水肿,真皮弥漫淋巴细胞,异型细胞具亲表皮性,免疫组化示:LCA(+),CD8(+),TIA(+),TCR基因重排阳性,诊断:亲表皮CD8+皮肤T细胞淋巴瘤。予以2次CHOP化疗,无效死亡。本病在国内首次报道,具有独特临床病理特点,早期累及皮外,侵袭性高,无有效治疗方法,预后差。

Male patient, 46 years old, systemic exudative erythema, scalp abscess in September. Pathological findings of lung, liver and skin tissues were found on admission examination: epidermal sponge edema, dermal diffuse lymphocytes, and anaplastic skin cells. Immunohistochemistry showed LCA (+), CD8 +, TIA +, TCR Gene rearrangement positive, diagnosis: pro-skin CD8 + cutaneous T-cell lymphoma. 2 CHOP chemotherapy, invalid death. The disease was first reported in China, has a unique clinical and pathological features, early involvement of the skin, high invasion, no effective treatment, the prognosis is poor.