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脂肪组织一直被认为是贮备能量的终末分化器官,近年研究证实脂肪组织可分泌20多种生物活性因子,如瘦素(leptin)、网膜素(omentin)、脂联素(adiponectin)、肿瘤坏死因子(TNF-α)、白介素-6(IL-6)等。这些脂肪因子通过作用于全身组织,调整脂肪的含量及分布,并广泛参与糖脂代谢平衡,改善血管内皮功能,从而调控机体多种相关机制。孕期胎盘合体滋养细胞亦大量分泌网膜素-1与瘦素;而现已证实后者参与妊娠期高血压疾病(hyperten-
Adipose tissue has long been considered as the terminal organ for the storage of energy. Recent studies have demonstrated that adipose tissue secretes more than 20 bioactive factors such as leptin, omentin, adiponectin, Necrosis factor (TNF-α), interleukin-6 (IL-6) and so on. These adipokines regulate various mechanisms of the body by acting on the body tissues, regulating the content and distribution of fat, and participating extensively in the balance of glycolipid metabolism, improving vascular endothelial function. Pregnancy placental syncytiotrophoblasts also secrete a large number of retinol-1 and leptin; and it has been confirmed that the latter involved in hypertensive disorders of pregnancy (hyperten-