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目的探讨新辅助化疗联合保乳手术治疗中晚期乳腺癌临床应用。方法对2005年1月至2008年1月中晚期乳腺癌患者38例回顾分析。结果本组病例经新辅助化疗后进行乳腺癌疗效评定,完全缓解(CR)7例,部分缓解(PR)22例、疾病稳定(SD)13例,无疾病进展(PD)病例,总有效率69.04%经新辅助化疗后采取保乳治疗29例,采取改良根治术9例。手术顺利,术中出血不多,无意外发生,术后恢复良好,切口均I期愈合,无并发症,对保留乳房的外形满意。随访时间12～36个月。随访期间均未出现局部复发,无死亡患者。2例患者出现远处转移。结论中晚期乳腺癌患者应积极采取新辅助化疗使肿瘤的体积缩小,肿瘤分期降低,提高保乳手术,使患者得到良好的疗效和乳房外形美观,提高女性生活质量。
Objective To investigate the clinical application of neoadjuvant chemotherapy and breast-conserving surgery in the treatment of advanced breast cancer. Methods A retrospective analysis of 38 patients with advanced breast cancer from January 2005 to January 2008. Results In this group, 7 cases of complete remission (CR), 22 cases of partial remission (PR), 13 cases of stable disease (SD) and no disease progression (PD) were evaluated. The total effective rate 69.04% after neoadjuvant chemotherapy to take breast-conserving treatment in 29 cases, to take modified radical mastectomy in 9 cases. Surgery was smooth, less bleeding during surgery, no accident, postoperative recovery was good, I incision healed, no complications, to retain the shape of the breast satisfaction. Follow-up time of 12 to 36 months. During the follow-up period, no local recurrence and no death occurred. 2 patients showed distant metastasis. Conclusions Neoadjuvant chemotherapy should be actively taken in patients with advanced breast cancer to reduce the size of the tumor, reduce the tumor stage, enhance the operation of breast-conserving surgery, make the patients get good curative effect and beautiful breast appearance, and improve the quality of life of women.