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[目的]探讨黄连素对根除幽门螺杆菌(Hp)和溃疡愈合的影响。[方法]将96例Hp阳性的消化性溃疡及慢性胃炎患者随机分为2组:对照组42例,给予标准三联疗法(克拉霉素、阿莫西林、雷贝拉唑);观察组54例,给予黄连素联合三联疗法。消化性溃疡患者治疗结束后4周复查电子胃镜观察溃疡愈合情况,所有患者治疗结束后4周复查13C-尿素呼气试验,判断Hp根除率,观察患者的不良反应发生情况。[结果]观察组与对照组比较,Hp根除率明显提高(P<0.05),不良反应发生率明显减少(P<0.05),消化性溃疡患者溃疡愈合情况差异无统计学意义(P>0.05)。[结论]三联疗法联合黄连素应用能提高Hp根除率,不良反应轻微,但对溃疡愈合无明显影响。
[Objective] To investigate the effect of berberine on the eradication of Helicobacter pylori (Hp) and ulcer healing. [Method] 96 cases of Hp-positive peptic ulcer and chronic gastritis patients were randomly divided into two groups: the control group of 42 patients given standard triple therapy (clarithromycin, amoxicillin, rabeprazole); observation group of 54 patients , Given berberine triple therapy. Peptic ulcer patients 4 weeks after the end of treatment review electron gastroscopy observed ulcer healing, all patients 4 weeks after the end of treatment review 13C-urea breath test to determine the Hp eradication rate, observation of patients with adverse reactions. [Result] The eradication rate of Hp in observation group was significantly higher than that in control group (P <0.05), and the incidence of adverse reactions was significantly decreased (P <0.05). There was no significant difference between the observation group and the control group in the healing of peptic ulcer patients (P> 0.05) . [Conclusion] The combination of triple therapy and berberine can improve the eradication rate of Hp with mild adverse reactions, but it has no obvious effect on ulcer healing.