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基质金属蛋白酶MMP 2和MMP 9是降解Ⅳ型胶原最主要的酶 ,在肺癌的侵袭转移中起重要作用。MMPs在各型肺癌中的表达均有明显增加 ,MMP 2 ,MMP 9的表达水平与肺癌预后具相关性。目前开发合成的数种MMP抑制剂已进入临床实验阶段
Matrix metalloproteinases MMP 2 and MMP 9 are the most important enzymes to degrade type IV collagen and play an important role in the invasion and metastasis of lung cancer. The expression of MMPs in all types of lung cancer were significantly increased, and the expression of MMP 2, MMP 9 was correlated with the prognosis of lung cancer. The current development and synthesis of several MMP inhibitors have entered the clinical trial phase