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目的:研究胃癌组织中环氧合酶2(COX-2)蛋白的表达变化及其意义。方法:采用免疫组化SABC法检测患有慢性浅表性胃炎、不典型增生、慢性萎缩性胃炎伴肠化生、胃癌患者胃粘膜病变组织中的COX-2蛋白表达量。结果:慢性浅表性胃炎COX-2蛋白表达阳性率为19.05%,慢性萎缩性胃炎伴肠化生阳性率为28.57%、不典型增生为42.31%,胃癌阳性率为61.70%,胃癌患者COX-2蛋白阳性率与其他病变组织相比差异显著(P>0.05),胃癌组织分级、有无淋巴结转移和癌细胞浸润深度都能影响COX-2蛋白表达。结论:COX-2蛋白在病变组织中的表达与胃癌细胞的侵袭和转移有关。
Objective: To study the changes of cyclooxygenase 2 (COX-2) protein in gastric carcinoma and its significance. Methods: Immunohistochemical SABC method was used to detect the expression of COX-2 protein in gastric mucosal lesions in patients with chronic superficial gastritis, dysplasia, chronic atrophic gastritis and intestinal metaplasia. Results: The positive rate of COX-2 protein in chronic superficial gastritis was 19.05%, the positive rate of chronic atrophic gastritis with intestinal metaplasia was 28.57%, the atypical hyperplasia was 42.31%, the positive rate of gastric cancer was 61.70% 2 protein was significantly different from that of other tissues (P> 0.05). The grade of gastric cancer, the presence of lymph node metastasis and the depth of cancer cell infiltration all could affect the expression of COX-2 protein. Conclusion: The expression of COX-2 protein in diseased tissues is related to the invasion and metastasis of gastric cancer cells.