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目的探讨乙型肝炎病毒携带产妇血清HBVDNA浓度对哺乳的影响。方法选择乙肝携带产妇145例,采用荧光定量聚合酶链反应(FQ-PCR)技术对产妇血清HBVDNA与乳汁HBVDNA的进行检测,并将产妇血清HBVDNA浓度分级,分析产妇血清不同HBVDNA浓度级对乳汁HBVDNA阳性率。结果当产妇血清HBVDNA<500copies/ml时,74例产妇的乳汁中检出HBVDNA阳性为零,当产妇血清HBVDNA浓度500～1e6copies/ml时,30例产妇乳汁中检出HBVDNA阳性为3例,阳性率为10%(3/30),当产妇血清HBVDNA浓度为≥1e6copies/ml时,41例产妇乳汁中检出HBVDNA阳性为36例,阳性率为87.8%(36/41)。结论当产妇血清HBVDNA浓度达到或超过1e6copies/ml时,乳汁中HBVDNA阳性率大幅度增加;而当产妇血清HBVDNA浓度小于1e6copies/ml时,乳汁中HBVDNA检出率低。
Objective To investigate the effect of hepatitis B virus (HBV) seropositive HBVDNA on breastfeeding. Methods One hundred and seventy-eight pregnant women with hepatitis B were enrolled in this study. Serum HBVDNA and serum HBV DNA were detected by fluorescence quantitative polymerase chain reaction (FQ-PCR). Serum HBVDNA level was also graded. Positive rate. Results When maternal serum HBVDNA was less than 500copies / ml, the positive rate of HBVDNA in the milk of 74 maternal women was zero. When maternal serum HBVDNA concentration was 500 ~ 1e6copies / ml, the positive rate of HBVDNA in 30 maternal milk samples was 3 The rate of HBVDNA in 41 cases of maternal milk was 36 (87.8%, 36/41) when the serum HBV DNA concentration was ≥1e6copies / ml. Conclusions The positive rate of HBVDNA in milk increased significantly when the serum HBVDNA level reached or exceeded 1e6copies / ml. However, the detection rate of HBVDNA in breast milk was low when the serum HBV DNA concentration was less than 1e6copies / ml.