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头孢菌素类药物中聚合物的多少是影响该类药物致敏性的关键因素。中国药典2000年版新增了头孢哌酮钠、头孢曲松钠、头孢噻肟钠、头孢他啶中聚合物的检测,其方法规定使用柱色谱法及玻璃色谱柱。应用该方法,实验中色谱体系平衡困难,样品分析时间长且重现性不好。我们藉此自制了不锈钢色谱柱,与HPLC系统连接,并对分析方法适当调整,节省了系统平衡及样品分析时间,分析重现性好,结果准确可靠。
Cephalosporins in the number of polymers is the key factor affecting the sensitization of these drugs. Chinese Pharmacopoeia 2000 edition of a new cefoperazone sodium, ceftriaxone sodium, cefotaxime sodium, ceftazidime polymer detection, the method requires the use of column chromatography and glass column. Using this method, the chromatographic system in the experiment was difficult to balance, the sample analysis time was long and the reproducibility was not good. We took this homemade stainless steel column, connected with the HPLC system, and the appropriate adjustment of the analysis method, saving system balance and sample analysis time, analysis and reproducibility, the results are accurate and reliable.