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目的了解延安地区居民原发性高尿酸血症患病情况及其影响因素。方法按照全国高尿酸血症流行病学调查方法,在4个调查点(包括社区、乡、镇)中抽取20~74岁常住人口1 290人进行调查,调查包括问卷、体格检查及生化检查。采用SPSS 13.5软件,率的比较采用χ2检验,P<0.05为差异有统计学意义。结果 (1)延安市居民高尿酸血症标化患病率5.4%。(2)高尿酸血症患病率男性显著高于女性(10.6%vs1.8%,χ2=47.06,P<0.05)。(3)高尿酸血症组和正常对照组合并高血压、血脂异常、空腹血糖受损(IFG)、糖耐量损害(IGT)、糖尿病的比例分别为39.4%、71.8%、46.5%、32.4%、21.1%和20.3%、33.6%、29.9%、22.4%、11.3%。(4)体质指数、腰围、臀围、收缩压、舒张压、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白与尿酸水平呈正相关;高密度脂蛋白与尿酸水平呈负相关;年龄与尿酸水平无明显相关性。结论延安地区高尿酸血症的危险因素主要有体质指数、血压、血脂、血糖等。
Objective To understand the prevalence of essential hyperuricemia among residents in Yan’an and its influencing factors. Methods According to the national epidemiological survey of hyperuricemia, 1,290 permanent residents aged from 20 to 74 were selected from 4 survey sites (including community, township and town) for investigation, including questionnaires, physical examination and biochemical tests. Using SPSS 13.5 software, rate comparison using χ2 test, P <0.05 for the difference was statistically significant. Results (1) The prevalence of hyperuricemia in Yan’an residents was 5.4%. (2) The prevalence of hyperuricemia in males was significantly higher than that in females (10.6% vs 1.8%, χ2 = 47.06, P <0.05). (3) The rates of hypertension, dyslipidemia, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and diabetes in hyperuricemia group and control group were 39.4%, 71.8%, 46.5% and 32.4% , 21.1% and 20.3%, 33.6%, 29.9%, 22.4%, 11.3%. (4) Body mass index, waist circumference, hip circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, triglycerides and low density lipoprotein were positively correlated with uric acid level; high density lipoprotein was negatively correlated with uric acid level; No significant correlation of uric acid levels. Conclusion The main risk factors of hyperuricemia in Yan’an are body mass index, blood pressure, blood fat, blood sugar and so on.