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目的:探讨甲钴胺联合a硫辛酸治疗糖尿病周围神经病变的临床效果。方法:2010年4月-2014年4月我院收治的糖尿病周围神经病病变156例患者,无定性随机分为两组,观察组78例和对照组78例。两组患者同时给予饮食指导以及平稳调控血糖等常规治疗的同时,给予甲钴胺0.5mg,肌注,1次/d,2周为一疗程。观察组与对照组同样使用甲钴胺注射液,在此疗基础上加用a硫辛酸,0.6g加入生理盐水250mL,静脉滴注,1次/d,2周为一疗程,注意避光滴注。结果:治疗2周后,观察组78例患者中显效20例,有效52例,无明显疗效6例,总有效率92.3%;对照组78例患者中显效8例,有效45例,无明显疗效25例,总有效率67.9%。两组患者比较临床总有效率,差异有统计学意义((P<0.05)。结论:甲钴胺联合a硫辛酸治疗糖尿病周围神经病变,临床效果得以验证,疗效甚佳,值得借鉴应用。
Objective: To investigate the clinical efficacy of mecobalamin combined with alpha lipoic acid in the treatment of diabetic peripheral neuropathy. Methods: From April 2010 to April 2014, 156 patients with diabetic peripheral neuropathy admitted to our hospital were randomly divided into two groups, 78 in observation group and 78 in control group. Two groups of patients given diet guidance and stable control of blood glucose and other conventional treatment at the same time, given mecobalamin 0.5mg, intramuscular injection, 1 / d, 2 weeks for a course of treatment. Observation group and control group also used mecobalamin injection, on the basis of the treatment with a lipoic acid, 0.6g added 250mL of normal saline, intravenous infusion, 1 / d, 2 weeks for a course of treatment, pay attention to dark spots Note. Results: After 2 weeks of treatment, 20 of 78 patients in observation group were effective, 52 patients were effective, 6 patients had no obvious effect, and the total effective rate was 92.3%. Among 78 patients in control group, 8 were effective and 45 were effective, with no significant effect 25 cases, the total efficiency of 67.9%. The clinical total effective rate of the two groups was statistically significant (P <0.05) .Conclusion: Mecobalamin combined with a lipoic acid in the treatment of diabetic peripheral neuropathy, the clinical effect has been verified, the effect is very good, it is worth learning from the application.