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目的探讨苯磺酸左旋氨氯地平联合依那普利治疗原发性高血压的疗效及安全性。方法选取2009年10月—2011年10月攀枝花市仁和区大河中路社区卫生服务中心收治的原发性高血压患者120例。根据高血压患者个体情况(年龄、身体状况、体质等)不同,采用适当剂量的苯磺酸左旋氨氯地平联合依那普利治疗。观察并记录所有患者治疗前及治疗2个月后血压控制情况,临床症状发生情况,心、脑、肾靶器官受损情况及心脑血管事件发生情况。结果血压控制总有效率为90.8%;患者临床症状完全消失87例(72.5%);治疗后患者头痛、乏力、头晕、眼花、耳鸣、注意力不集中、失眠发生率低于治疗前,差异均有统计学意义(P<0.05);靶器官损伤恢复率为61.5%;心脑血管事件发生率为2.5%。结论苯磺酸左旋氨氯地平联合依那普利治疗原发性高血压的疗效显著,可保护靶器官功能,且心脑血管事件发生率低,安全性高。
Objective To investigate the efficacy and safety of levamlodipine besylate combined with enalapril in the treatment of essential hypertension. Methods From October 2009 to October 2011, 120 patients with essential hypertension were admitted to Dahezhong Road Community Health Service Center, Renhe District, Panzhihua City. According to the individual patients with hypertension (age, physical condition, physical, etc.) is different, the appropriate dose of levamlodipine besylate combined with enalapril treatment. Observe and record all patients before treatment and after 2 months of treatment blood pressure control, clinical symptoms, heart, brain, kidney target organ damage and cardiovascular events. Results The total effective rate of blood pressure control was 90.8%. The clinical symptoms disappeared completely in 87 patients (72.5%). After treatment, the headache, fatigue, dizziness, vertigo, tinnitus, attention deficit and insomnia were lower than those before treatment (P <0.05). The target organ damage recovery rate was 61.5% and the incidence of cardiovascular and cerebrovascular events was 2.5%. Conclusion Levamlodipine besilate combined with enalapril has significant curative effect on essential hypertension, which can protect the function of target organ and the incidence of cardiovascular and cerebrovascular events is low and the safety is high.