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目的:了解佛山市高明区7岁以下儿童乙型肝炎表面抗体(HBs Ab)含量水平,表面抗体阳性率在不同年龄间差异。方法:选取2014年10月至2015年9月在佛山市高明区人民医院门诊检查的7岁以下儿童2391人,抽取静脉血作乙型肝炎两对半定性分析和HBs Ab定量检测。结果:总体Hbs Ag阳性率0.21%,HBs Ab阳性率57.38%;不同年龄组别儿童HBs Ab阳性率差异存在统计学意义;5岁以下儿童HBs Ab含量≤100 m IU·m L~(-1)构成比随年龄增长而上升,超过一半3岁儿童需进行乙型肝炎疫苗加强免疫。结论:有必要开展辖区儿童乙型肝炎表面抗体监测。高危婴幼儿年龄为7~12月,一般儿童在3岁左右进行乙型肝炎表面抗体定量检测,当HBs Ab含量小于100 m IU·m L~(-1)时需加强免疫。
Objective: To understand the level of HBs Ab in children under 7 years old in Gaoming District of Foshan City. The positive rate of surface antibody was different between different ages. Methods: From October 2014 to September 2015, 2,391 children under 7 years of age undergoing outpatient examination at People’s Hospital of Gaoming District of Foshan City were enrolled. Two venous blood samples were collected for two-factor semi-qualitative analysis and quantitative detection of HBs Ab. Results: The overall positive rate of HBsAg was 0.21%, and the positive rate of HBsAb was 57.38%. The positive rates of HBs Ab in different age groups were statistically significant. The HBs Ab content in children under 5 years old was less than or equal to 100 m IU · m L -1 ) Composition ratio increases with age, more than half of 3-year-old children need to be Hepatitis B vaccine to strengthen immunity. Conclusion: It is necessary to carry out monitoring of HBsAg in children in their jurisdiction. High-risk infants and young children aged 7 to 12 months, the average child at about 3 years of hepatitis B surface antibody quantitative detection, when HBs Ab content of less than 100 mIU · m L -1 need to be strengthened immunity.