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目的比较液基细胞学技术与传统细胞学涂片在宫颈鳞状细胞病变检测中的差异。方法 2008年1月—2012年1月采用液基细胞学技术及传统细胞学涂片对1 880名妇女进行筛查,并对筛查阳性病例以阴道镜检查及病理活检结果为金标准作为阳性对照,评估液基细胞学技术对宫颈不同病变的诊断价值。结果液基细胞学筛查出非典型鳞状细胞(atypical squamous cells of undeter mined significance,ASCUS)及以上病例282例,阳性检出率为15.0%;传统细胞学涂片筛查出巴氏ⅡB级及以上病例84例,阳性检出率为4.5%。液基细胞学阳性检出率明显高于传统细胞学涂片,二者比较差异有统计学意义(P<0.05)。以阴道镜及病理组织学检查结果为金标准,液基细胞学筛查符合率为73.40%,传统细胞学涂片筛查符合率为53.57%,二者比较差异有统计学意义(P<0.05)。结论液基细胞学技术筛查宫颈鳞状细胞病变明显优于传统细胞学涂片。
Objective To compare the difference between liquid-based cytology and traditional cytology smears in the detection of cervical squamous cell lesions. Methods From January 2008 to January 2012, 1880 women were screened using liquid-based cytology and conventional cytology smears. The results of colposcopy and pathological biopsy were positive for screening positive cases Control, evaluation of liquid-based cytological techniques for the diagnosis of different lesions of the cervix. Results A total of 282 cases of atypical squamous cells of undetermined mined significance (ASCUS) and above were screened by liquid-based cytology. The positive detection rate was 15.0% And 84 cases of the above, the positive detection rate was 4.5%. The positive rate of liquid-based cytology was significantly higher than that of traditional cytology smears, the difference was statistically significant (P <0.05). Colposcopy and pathological examination results as the gold standard, liquid-based cytology screening coincidence rate was 73.40%, the traditional cytology smear screening coincidence rate was 53.57%, the difference was statistically significant (P <0.05 ). Conclusion liquid-based cytological screening of cervical squamous cell lesions was significantly better than the traditional cytology smears.