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曾报道接触有机溶剂的工人会出现亚临床神经心理功能障碍,但混合有机溶剂的行为毒性仍是个争论的问题。本文主要研究有机溶剂是否具有神经毒性。如果有,是否存在剂量-反应关系等问题。为了排除混淆因素所生产的系统偏倚,作者从芬兰国家登记册上4300对同性别成年的同卵双生子中选出21对(男11对,女10对),以消除来自生物遗传、儿童期生长条件、年龄等因素的影响。受试者一部分接触有机溶剂,而另一部分不接触,组成对子进行配对研究。另
Sub-clinical neuropsychological dysfunction has been reported in workers exposed to organic solvents, but the behavioral toxicity of mixed organic solvents remains a matter of debate. This article focuses on whether organic solvents are neurotoxic. If so, whether there is a dose-response relationship and other issues. In order to rule out systemic bias in confounding factors, the authors selected 21 pairs (11 males and 10 females) of the 4300 same-sex identical twins in the Finnish Register of Nations to eliminate the genetic bias from childhood, Growth conditions, age and other factors. Subjects were exposed to organic solvents, while others were untouched, and the paired pairings were made. another