论文部分内容阅读
体内应用雷公藤多甙（ＴⅡ），Ⅰａ单抗（２１－２）及树突状细胞单抗（ＷＺＤ３）分别处理ＳＤ大鼠（连续１０ｄ），以观察其对细胞和体液免疫功能的影响。结果表明：ＴⅡ灌胃和２１－２，ＷＤＺ３静脉注射各组，混合淋巴细胞增殖反应（ＭＬＲ）和对Ｃｏｎ－Ａ刺激的淋巴细胞增殖反应能力皆明显降低，与对照组相比Ｐ＜０．０５。此外ＴⅡ灌胃与ＷＤＺ３静脉注射联合应用显示较强的细胞免疫抑制作用，在ＭＬＲ中与ＴⅡ单独处理相比Ｐ＜０．０５，但与ＷＺＤ３单独应用相比无显著差异（Ｐ＞０．０５）。经定量溶血测定法（ＱＨＳ）检测各组溶血素水平亦呈现相似结果。
In vivo application of Tripterygium wilfordii (TII), Ia monoclonal antibody (21-2) and dendritic cell monoclonal antibody (WZD3) to SD rats (for 10 days) were performed to observe their effects on cellular and humoral immunity. The results showed that: TII gavage and 21-2, WDZ3 intravenous injection of each group, mixed lymphocyte proliferative response (MLR) and Con-A stimulated lymphocyte proliferative response were significantly reduced, compared with the control group P <0. 05. In addition, TII gavage combined with WDZ3 intravenous injection showed strong cellular immunosuppressive effect, which was P<0.05 compared with TII alone in MLR, but there was no significant difference compared with WZD3 alone (P>0.05). ). Quantitative hemolysis assay (QHS) also showed similar results for hemolysin levels in each group.