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为探讨类风湿性关节炎(RA)与血清β_2-微球蛋白(β_ 2-MG)的关系,我们采用放免法对28例RA患者空腹外周血β_2-MG水平进行了测定,并与20例正常人作了对照。结果:RA患者β_2-MG(mg/L)水平:晚期(4. 97±1.21,n=14)、中期(3.66±1.37,n=8)、早期(2.87±1.04,n=6)均比对照组(1.64±0.48,n=20)明显增高(P<0.01,P<0.01,P<0.05),且与病情严重程度呈正相关。提示测定β_2-MG可了解RA时机体免疫状况,并对病情的轻重加以判断。
To investigate the relationship between rheumatoid arthritis (RA) and serum β_2-microglobulin (β_2-MG), we measured the level of β_2-MG in peripheral blood of 28 patients with RA by radioimmunoassay and compared with 20 patients Normal people as a control. Results: The levels of β 2-MG (mg / L) in patients with RA were significantly higher than those in patients with advanced RA (4.97 ± 1.21, n = 14), middle (3.66 ± 1.37, n = 8) Control group (1.64 ± 0.48, n = 20) was significantly higher (P <0.01, P <0.01, P <0.05), and was positively correlated with the severity of the disease. Prompt determination of β_2-MG can understand the immune status of RA, and to determine the severity of the disease.