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目的:探讨血清CA724与其他肿瘤标志物(TM)联检对肺癌的诊断价值。方法:用电化学发光免疫分析仪检测93例肺癌患者血清CA724、CEA、CA199、CA125和CA153的水平,分别计算单项TM及CA724与其他TM组合的各项评价指标。结果:CA724对肺癌诊断的特异度为96.4%,阳性预测值87.5%高于其他四项TM,CA724+CEA+CA199联检准确度为70.5%,敏感度为47.2%。结论:CA724可作为肺癌筛查的指标,CA724+CEA+CA199联检组合在提高敏感度的同时,也提高诊断的准确度,有助于肺癌的早期诊断。
Objective: To investigate the diagnostic value of serum CA724 in combination with other tumor markers (TM) for lung cancer. Methods: The levels of serum CA724, CEA, CA199, CA125 and CA153 in 93 patients with lung cancer were detected by electrochemiluminescence immunoassay. The evaluation indexes of single TM and CA724 combined with other TM were calculated. Results: The specificity of CA724 in the diagnosis of lung cancer was 96.4%, the positive predictive value was 87.5% higher than the other four TMs. The accuracy of the combined detection of CA724 + CEA + CA199 was 70.5% and the sensitivity was 47.2%. Conclusion: CA724 can be used as an indicator of lung cancer screening. The combination of CA724 + CEA + CA199 can improve the sensitivity as well as improve the diagnostic accuracy and contribute to the early diagnosis of lung cancer.