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目的对CT引导下经皮肺穿刺冷循环射频消融治疗晚期肺癌的有效性和安全性进行研究评价。方法对32例102个不同病理类型的晚期肺癌行冷循环射频消融治疗,观察治疗过程中血压、脉搏和周围血氧饱和度的变化;治疗前后肝肾、肺功能的改变;以及CT扫描肿瘤组织中低密度影和肿瘤体积的变化。结果 32例晚期肺癌患者冷循环射频消融治疗中血压、脉搏及周围血氧饱和度无明显改变;治疗后肝肾功能、肺功能无明显改变;治疗后1个月内CT扫描见肿瘤体积较术前有所增大,3个月后102个肿瘤中出现CR 23个(100%缩小),PRa 53个(80%～100%缩小),PRb 24个(50%～80%缩小),NR 2个(缩小<50%);治疗后第3个月肿瘤内低密度影Ⅰ型2个,Ⅱ型43个,Ⅲ型57个。结论冷循环治疗晚期肺癌创伤小,近期疗效好,比较安全,可作为一种新的安全有效的治疗方法。
Objective To evaluate the efficacy and safety of CT guided percutaneous pulmonary puncture and radiofrequency ablation in the treatment of advanced lung cancer. Methods 32 cases of 102 advanced lung cancer with different pathological types were treated with cold-cycle radiofrequency ablation. The changes of blood pressure, pulse and peripheral oxygen saturation during treatment were observed. The changes of liver, kidney and lung function before and after treatment were observed. Medium and low density changes in tumor size and volume. Results There were no significant changes in blood pressure, pulse rate and peripheral oxygen saturation in 32 cases of patients with advanced lung cancer after radiofrequency ablation of cold cycle. There was no significant change in liver and kidney function and pulmonary function after treatment. The volume of CT scan in one month after treatment was higher than that in operation There were 23 CR (100% reduction), PRa 53 (80% -100% reduction), PRb 24 (50% -80% reduction), NR 2 There were 2 (type Ⅰ), type Ⅱ (type Ⅱ) and type Ⅲ (type Ⅲ) 57 cases in the third month after treatment. Conclusion Cold cycle treatment of advanced lung cancer trauma, the recent good effect, more safe, as a new safe and effective treatment.