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为了观察经口或鼻胃管服用复方嗜酸杆菌片有效预防早产儿真菌感染的临床效果,选择住院的早产儿,应用抗生素时间均长达7 d以上。随机分成2组,对照组入院后给予常规防治感染及对症支持,于入院第15 d开始口服或鼻胃管鼻饲氟康唑直至出院。治疗组在早产儿入院开始使用抗生素时即给予口服复方嗜酸杆菌片,直至出院。结果显示对照组与治疗组新生儿在应用抗生素后7 d发生真菌感染无统计学意义(P>0.05),但在14 d发生真菌感染有显著差异,有统计学意义(P<0.05),对照组与治疗组新生儿在21 d发生真菌感染有显著差异,有统计学意义(P<0.05),28 d后发生真菌感染无统计学意义(P>0.05)。且<1 500 g的新生儿在相同体重下口服益生菌后可降低真菌感染发病率,有统计学意义(P<0.05)。益生菌有效预防早产儿真菌感染,同时能避免抗真菌药物所致不良反应,值得临床推广应用。
In order to observe the oral or nasogastric administration of compound acidophilus tablets effective prevention of fungal infection in preterm infants clinical results, choose hospitalized premature children, the application of antibiotics for up to 7 d or more. The patients in the control group were given routine anti-infection and symptomatic support after admission. At the 15th day after admission, oral or nasogastric nasal feeding of fluconazole was started until they were discharged from the hospital. The treatment group was given oral administration of compound acidophilus tablets when the antibiotics were given to the premature infants until hospital discharge. The results showed that there was no significant difference in fungal infection between the control group and the treatment group on the 7th day after application of antibiotics (P> 0.05), but the fungal infection was significantly different at 14 days (P <0.05) There were significant differences in fungal infection between newborns and treatment groups on day 21 (P <0.05), but no significant difference (P> 0.05) occurred after 28 days. And <1 500 g of newborns oral probiotics at the same weight can reduce the incidence of fungal infection, with statistical significance (P <0.05). Probiotics effectively prevent fungal infections in preterm infants and avoid adverse reactions caused by antifungal drugs, which is worthy of clinical application.