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目的:回顾分析利福平致肾功能损伤病例资料,提出其规律特点供临床参考.方法:收集国内有关医学文献1991年～1998年发表的利福平致肾功能损害病例报道32例进行综合分析.结果:利福平致肾功能损害与剂量大小、停药时间等无关,而与利福平曾用史、患者过敏体质等因素相关.结论:临床应用利福平前应详细询问患者,曾有过敏史者禁用;应用利福平后有早期过敏症状应立即停药.“,”Objective:To analyse the rifampiein-induced renal insufficiency for clinical reference.Methods:The data of 32 cases were collected and reviewed from the national journals of 1991-1998.Results:Rifampicin-in duced renal insufficiency related to the drug taken in the past and the hypersensitive constitution,yet it was in no relation with the dosage and discontinuous duration of the drug.Conclusion:Rifampicim would be cautiously tried for patients in clinical practice.The patient with allergic history should not take it;he should stop the drug immediately when allergic signs appeared at the early stage of administration.