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目的分析宫颈上皮内瘤变(CIN)及宫颈癌患者血清白介素-23A(IL-23A)和白介素-17A(IL-17A)的表达情况及其临床应用价值。方法选取2013年1月-2016年1月解放军第一七四医院妇科收治的127例CIN及36例宫颈癌患者为研究对象。比较术前不同级别CIN及宫颈癌患者血清IL-23A及IL-17A的表达情况,分析IL-23A及IL-17A与人乳头瘤病毒(HPV)感染的关系;并探讨IL-23A及IL-17A对CIN及宫颈癌患者预后评估的价值。结果对照组、低CIN组、高CIN组及宫颈癌组患者血清IL-23A及IL-17A水平依次升高,差异有统计学意义(P<0.05);各组HPV单一感染患者血清IL-23A及IL-17水平均低于复合感染患者,差异均有统计学意义(均P<0.05);CIN及宫颈癌术后高危HPV感染持续阳性患者血清IL-23A及IL-17水平均高于HPV转阴患者,差异均有统计学意义(均P<0.05)。结论 IL-23A及IL-17A作为机体质量要的炎性介质在高危型HPV感染导致的CIN及宫颈癌的发生发展过程中起重要作用。
Objective To analyze the expression of interleukin-23A (IL-23A) and interleukin-17A (IL-17A) in patients with cervical intraepithelial neoplasia (CIN) and cervical cancer and its clinical value. Methods From January 2013 to January 2016, 127 cases of CIN and 36 cases of cervical cancer admitted to the 174th Hospital of PLA were enrolled in this study. 23A and IL-17A in patients with cervical intraepithelial neoplasia (CIN) and cervical cancer were analyzed retrospectively. The relationship between IL-23A, IL-17A and human papillomavirus (HPV) infection was analyzed. The levels of IL-23A and IL- 17A on the prognosis of patients with CIN and cervical cancer. Results The serum levels of IL-23A and IL-17A in control group, low CIN group, high CIN group and cervical cancer group increased in turn, with statistical significance (P <0.05). The serum levels of IL-23A (All P <0.05). The serum levels of IL-23A and IL-17 in patients with persistent positive HPV infection after CIN and cervical cancer were all higher than that of HPV Patients with negative, the difference was statistically significant (P <0.05). Conclusion IL-23A and IL-17A, as the important mediators of body mass, play an important role in the development of CIN and cervical cancer caused by high-risk HPV infection.