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In our recently co-authored Physiological Reviews manuscript entitled The biology of regeneration failure and success after spinal cord injury (Tran et al.,2018b),we sought to provide a comprehensive and up-to-date description of how the glial scar develops following spinal cord injury (SCI) to chronically inhibit axon regeneration.Our additional intention was to clarify some of the confusion in the field relating to an oversimplified view of the glial scar.