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扎莫特罗(Xamoterol,简称XAM)是一种选择性部分β_1受体激动剂,其激动活性约为完全激动剂异丙肾上腺素的43%。本文采用随机、双盲、交叉试验比较了XAM和地高辛对慢性房颤病人的症状、运动能力和24小时心率的影响。方法 13例慢性房颤病人,6例未用特殊治疗,6例服用地高辛,1例服用阿替洛尔,但研究前2周均停用上述药物。本研究分三个治疗期,每期持续2周,每期之间为2周的清洗期。所有病人在每治疗期时分别随机给予XAM(200mg,每日2次)、地高辛(头
Xamoterol (XAM) is a selective β 1 receptor agonist with an agonistic activity of about 43% of that of the isoprenaline-fully agonist. This randomized, double-blind, crossover trial compared XAM and digoxin in patients with chronic atrial fibrillation symptoms, exercise capacity and 24-hour heart rate. Methods Thirteen patients with chronic atrial fibrillation were treated with no special treatment, 6 with digoxin, and 1 with atenolol, but the above drugs were discontinued two weeks before the study. The study divided into three treatment periods, each period lasting 2 weeks, each period of 2 weeks of cleaning period. All patients were randomized to receive either XAM (200 mg twice daily), digoxin