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利用ELISA双抗体夹心法检测65例血液恶性疾病患者血浆D-二聚体含量。与正常对照组相比,急性白血病组D-二聚体水平增高具有显著性差异,尤以M3型患者更显著(8.54±5.70)mg/L(P<0.001)。淋巴瘤及慢粒患者升高不显著。24例急性髓性白血病完全缓解(CR)后,D-二聚体水平达到正常水平(0.31±0.10)mg/L。5例复发者D-二聚体再度升高(7.715±2.31)mg/L,与CR期比较差异有显著性意义。表明动态观测D-二聚体的血浆水平变化,有助于对白血病病情的判断和疗效观察。
Plasma D-dimer levels were measured in 65 patients with hematological malignancies by ELISA double antibody sandwich method. Compared with the normal control group, the level of D-dimer in acute leukemia group was significantly increased, especially in the M3 group (8.54 ± 5.70) mg / L (P <0.001). Lymphoma and CML patients did not increase significantly. D-dimer reached a normal level (0.31 ± 0.10) mg / L after complete remission (CR) of 24 patients with acute myeloid leukemia. D-dimer in 5 cases of relapse increased again (7.715 ± 2.31) mg / L, which had significant difference with CR stage. D-dimer shows dynamic changes in plasma levels, contribute to the judgment of leukemia and the efficacy of the observation.