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自1888年Ehrlich氏首先报告本病迄今已近百年,但有关本病的发病机理方面仍未解决,近年来由于细胞培养技术的提高,实验免疫学的进展、放射性同位素的应用及其他一些新技术的开展,对于发病机理方面各家学派提出了如下的意见。一、干细胞质和量的异常所谓质的异常是指多能干细胞的特有能力——自我复制和分化之间的平衡失调,所谓量的异常是指CFu-s或CFu-c绝对数的减少。Hansi氏认为再障是由于多能干细胞的缺陷,导致各早期细胞维持正常增生的能力降低;但也有学者认为是定向干细胞的缺陷
Since 1888, Ehrlich’s first report of the disease nearly a hundred years so far, but the pathogenesis of this disease has not been resolved in recent years due to increased cell culture technology, the progress of experimental immunology, the application of radioisotopes and other new technologies The development of various schools of pathogenesis for the following opinions. First, the abnormal quality and quantity of stem cells The so-called qualitative abnormalities refers to the unique ability of pluripotent stem cells - imbalance between self-replication and differentiation disorders, the so-called quantitative abnormalities refers to the reduction of CFu-s or CFu-c absolute number. Hansi believes that aplastic anemia is due to the defects of pluripotent stem cells, resulting in a decrease in the ability of all the early cells to maintain normal proliferation. However, some scholars think that it is a defect of directional stem cells