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目的:探讨微囊牛肾上腺嗜铬细胞(BCC)移植治疗晚期癌痛的有效性。方法:用胶原酶消化分离BCC,用海藻酸钠-聚赖氨酸-海藻酸钠(APA)包埋BCC,将APA微囊BCC植入急慢性疼痛动物模型大鼠和晚期癌痛患者的蛛网膜下隙观察镇痛效果。结果:APA微囊BCC对急慢性疼痛动物模型有明显镇痛作用。34例晚期癌痛患者的VAS评分移植前为8.86±0.94,移植后3天为2.36±1.81。移植后13例患者停用吗啡类药物(占38%),16例吗啡类药物用量减少(占47%),5例吗啡类药物用量无明显变化(占15%)。移植后生存3个月的16例患者中,8例吗啡类药物仍处于用量减少状态,8例无需应用。移植后1例患者生存5个月也未使用吗啡类药物。结论:APA微囊BCC对急慢性疼痛动物模型和晚期癌痛患者有明显的镇痛作用。
Objective: To investigate the effectiveness of microencapsulated bovine adrenal chromaffin cells (BCC) in the treatment of advanced cancer pain. Methods: BCC was isolated by collagenase digestion, BCC was embedded in sodium alginate - polylysine - sodium alginate (APA), APA microcapsule BCC was implanted into the cobweb of acute and chronic pain animal model rats and patients with advanced cancer pain Analgesia effect observed under the subfragment. Results: APA microcapsule BCC has obvious analgesic effect on acute and chronic pain animal model. The VAS score of 34 patients with advanced cancer pain was 8.86 ± 0.94 before transplantation and 2.36 ± 1.81 after 3 days of transplantation. Morphine drugs were discontinued in 13 of the 13 patients (38%), 16 morphine users (47%) and 5 morphine users (15%). Of the 16 patients who survived 3 months after transplantation, morphine was still in a state of reduced dosage in 8 patients, and 8 patients were not required. One patient survived 5 months after transplantation and did not use morphine. Conclusion: APA microcapsule BCC has obvious analgesic effect on acute and chronic pain animal models and patients with advanced cancer pain.