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已知铅能引起人和动物肾结构和功能性损伤,且铅能通过人胎盘屏障在胎儿体内蓄积。在胚胎发育期,胚胎的生长发育及其功能易受母体营养状况和摄入的外源性化学物质的影响。本研究旨在了解铅对怀孕期缺铁状况下妇女后代肾毒性的影响。实验选用鼠龄为90天雌性大鼠(160±10g),随机分成2大组。正常饲料组大鼠进食硫酸铵铁(94mg/100g)的配制饲料,缺铁饲料组大鼠先进食无铁饲料,15天后再进食铁含量仅为1/2日需要量(47
Lead is known to cause renal structural and functional damage in humans and animals, and lead accumulates in the fetus through the human placental barrier. During embryonic development, embryonic growth and development are susceptible to maternal nutrition and exposure to exogenous chemicals. The aim of this study was to understand the effect of lead on nephrotoxicity of the offspring of women during iron deficiency during pregnancy. Female SD rats (160 ± 10g) aged 90 days were randomly divided into 2 groups. The rats in the normal feed group were fed with the formulated diet of ammonium sulfate (94mg / 100g). The rats in the iron-deficient diet fed with iron-free diet for 15 days and the re-fed iron content of only 1 / 2day (47