Single-cell RNA-seq reveals the immune escape and drug resistance mechanisms of mantle cell lymphoma

• 作 者: Liang Wang Steven Mo Xin Li Yi
• 机 构: DepartmentofHematology,BeijingAdvancedInnovationCenterforBigData-BasedPrecisionMedicine,NanningLife-
• 出 处: 癌症生物学与医学:英文版
• 发表日期: 2020年3期
• 关键词: Cell heterogeneity immune escape mantle cell lymphoma multidrug resistance scRNA
• 基金项目: This work was supported by grants from the National Natural Science Foundation of China(Grant No.81873450),the Open Research Fund from Beijing Advanced Innovation Center for Big Data-Based Precision M

Objective:Mantle cell lymphoma(MCL)is a rare subtype of non-Hodgkin lymphoma(NHL)with high heterogeneity and a high recurrence rate.How heterogenous cell populations contribute to relapse remains to be elucidated.Methods:We performed single cell RNA seque