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1971年编者曾讨论过用细胞毒性制剂化疗后发生急性髓性白血病(简标AML)的问题。那时报告的多为骨髓瘤和慢性淋巴细胞型白血病化疗后的病例,近年又报道了许多发生在何杰金氏病化疗后的病例。但这些病例中,有的还作过放疗,因此是否由细胞毒性药物引起,还有疑问。而且,骨髓瘤和慢性淋巴细胞型白血病未经化疗也偶有发生AML的,这就更不能排除其自然发生的可能。小鼠实验说明AML和骨髓瘤之间有一定关系。因此AML的发生
In 1971 the editor discussed the issue of acute myelogenous leukemia (AML) after chemotherapy with cytotoxic agents. At that time, mostly reported cases of myeloma and chronic lymphocytic leukemia after chemotherapy, and in recent years have reported many cases of Hodgkin’s disease after chemotherapy. However, some of these cases have also been treated with radiotherapy and therefore whether they are caused by cytotoxic drugs or not. Moreover, myeloma and chronic lymphocytic leukemia also occur without chemotherapy AML, which can not even rule out the possibility of its natural occurrence. Mouse experiments show that there is a relationship between AML and myeloma. So AML happened